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Xeomin – IncobotulinumtoxinA for Treatment of Cervical Dystonia, Blepharospasm

Xeomin, IncobotulinumtoxinA based, is the name of a BoNTA-INCO product we used here at DermRealm. BoNTA-INCO was approved by the FDA back in 2010 for treatment of cervical dystonia and blepharospasm, following a proven good track record in many other countries around the globe – specifically in Germany, where it has been in use since 2005. Despite its relatively short history, BoTNA-INCO has gained wide acclaim and has seen extensive research and interest, and its market growth has been rapid with more than 261,000 patients treated worldwide. BoNTA-INCO is approved in 20 countries. In 2011 the FDA approved BoTNA-INCO for the treatment of glabellar lines. BoNTA-INCO became widely available in the United States in spring 2013.

Xeomin for treatment of:

Cervical Dystonia

Cervical dystonia, also called spasmodic torticollis, is a painful condition in which your neck muscles contract involuntarily, causing your head to twist or turn to one side. Cervical dystonia can also cause your head to uncontrollably tilt forward or backward. Cervical dystonia is a rare disorder that may occur at any age, even in infancy, however cervical dystonia most often occurs in middle-aged people. Women are more like men to experience cervical dystonia. There is no cure for cervical dystonia, however the disorder sometimes resolves without treatment, but sustained remissions are uncommon. Injecting botulinum toxin into the affected muscles often reduces the signs and symptoms of cervical dystonia.



Blepharospasm is the involuntary closing of the eyes and increased blinking. Blepharospasm is often described as eye dystonia, or adult onset focal dystonia. When blepharospasm occurs with dystonia in the face, specifically the mouth/jaw (oromandibular dystonia), the term Meige’s syndrome may be used. Blepharospasm affects the eye muscles and usually begins gradually with excessive blinking and/or eye irritation. In its early stages it may only occur in some circumstances, such as by bright lights, fatigue, and emotional tension. It is almost always present in both eyes. As the condition progresses symptoms may occur frequently during the day. In some cases the spasms disappear during sleep and spasms do not reappear for several hours after waking.


Glabellar Lines

Glabellar lines are sometimes called frown lines, and are the wrinkles that form between the brows caused by muscles contracting. After many years of wrinkling, those frown lines start to linger longer and can become quite pronounced. These are known as Glabellar lines, as they reside in the glabellar region of the face between the eyebrows above the nose.

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